Phillies vs Astros Prediction, Picks & Odds Tonight

Is the Philadelphia Phillies' Ranger Suarez in for a productive evening on the mound? We take a look in our Phillies vs Astros prediction.

Sean Tomlinson

Last Updated: June 24, 2025 4:59 PM EDT • 3 minute read

PHILLIES VS ASTROS PREDICTION, PICKS & ODDS TONIGHT — Pictured: Philadelphia Phillies starting pitcher Ranger Suarez throws a pitch against the Toronto Blue Jays: Photo by Kyle Ross via Imagn Images

The Philadelphia Phillies and Houston Astros square off tonight in a tilt between World Series odds contenders as we offer our Phillies vs. Astros prediction.

We focus our attention on Ranger Suarez, who should be in for a productive outing.

The Astros are the -140 favorites at our best sports betting sites for tonight's game, which starts at 8:10 p.m. ET from Daikin Park in Houston.

Phillies vs Astros prediction

My Phillies vs Astros best bet: Ranger Suarez Over 4.5 strikeouts (-140 via DraftKings)

Several of our other best MLB betting sites are sitting around -150 for this bet, including BetMGM at -155. Even more notably, the industry-leading trading team at Pinnacle is that much further at -159.

We're getting marginal value here then when price shopping among the best sports betting sites. That becomes even more appealing when taking into account the multiple projections putting Suarez's strikeout total significantly beyond 4.5. He's being widely projected for 5.5.

What's going against Suarez tonight is that the Astros simply don't strike out much, recording the third-fewest leaguewide. That punchout frequency gets even lower against lefties like Suarez, with Houston tallying a league-best 91.

But the bar here is low for Suarez, even when factoring in the Astros' strikeout numbers. He's gone below this total just once across nine starts this season, a stretch that includes striking out six Toronto Blue Jays batters, a team that's whiffed the second-fewest times against lefties.

Phillies vs Astros same-game parlay (SGP)

Ranger Suarez Over 4.5 strikeouts (-140)
Under 7.5 (-119)
No runs first inning (-140)

+310 via DraftKings

Suarez has long been forgiven for his tough debut outing after missing the first month and change due to a back injury. He's given up 14 earned runs across 57 1/3 innings this campaign, and half of that total came during his season-opening blowup.

He can certainly do his part to keep the scoring low, as can Valdez of the Astros. His 3.09 ERA sits 23rd leaguewide and 12th in the American League. He's masterful at inducing weak contact, with his ground ball rate that sits in the 97th percentile, according to Baseball Savant.

Phillies vs Astros odds

Phillies vs Astros live odds

View matchup | View all MLB odds

Phillies vs Astros opening odds

Moneyline: Astros (-140) | Phillies (+120)
Run line: Astros -1.5 (+140) | Phillies +1.5 (-190)
Over/Under: Over 7.5 (+105) | Under 7.5 (-125)

Phillies vs Astros updated betting insights

Updated betting info via BetMGM.

52% of bets are on the Phillies
The Astros opened as -145 moneyline favorites. That line hasn't moved
The total is set at 7.5 runs. There has been no movement on the total, with the Over at +100 and the Under -120

Phillies vs Astros trend

The Phillies have won eight of their last 10 games, often in dominant fashion. They boast a whopping plus-28 run differential during that stretch.

How to watch Phillies vs Astros and game info

Location	Daikin Park, Houston
Date	June 24, 2025
First pitch	8:10 p.m. ET
TV	NBC Sports Philadelphia
Phillies starting pitcher	Ranger Suarez (6-1, 2.20 ERA)
Astros starting pitcher	Framber Valdez (8-4, 3.09 ERA)

Phillies vs Astros latest injuries

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Written by:
Sean Tomlinson

Sean Tomlinson has been in the sports media wilderness since 2009, and he joined Sportsbook Review in 2021. His work has been referenced in The New York Times and Forbes. He's also made appearances on The Fan 590 and TSN 1050. Sean is a regular bettor who places bets daily while using a handful of books. Most frequently, he uses FanDuel and bet365 due to the quality experience on those apps. While he'll often take an analytical approach, Sean enjoys the fun, recreational side of betting too, and embraces alternative markets on events like the Westminster Dog Show or Eurovision, or the many novelty props tied annually to the Super Bowl, for example. Beyond sports, Sean is also interested in the betting markets tied to politics, and especially those connected to American elections. He sees betting as a way to explore and engage in a deeper way, and takes that same view to his work. He plays poker periodically too, and is an avid fantasy sports player. Sean also previously spent time with Bleacher Report and theScore, all after earning his media studies degree from the University of Guelph-Humber.