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Knicks vs. Pistons Prediction: Game 6 Odds & Expert Picks

Rob Paul

Last Updated: April 30, 2025 11:23 AM EDT • 3 min 19 sec read.

Knicks vs. Pistons Prediction: Game 6 Odds & Expert Picks, May 1
Pictured: New York Knicks guard Jalen Brunson (11) looks to pass the ball. Photo by Brad Penner-Imagn Images.

The Detroit Pistons have turned back the clock to 2004 with their defense helping them force a Game 6 against the New York Knicks on Thursday night at 7:30 p.m. ET (TNT, truTV) from Little Caesars Arena in Detroit.

Our Knicks vs. Pistons prediction, as part of our NBA picks for the NBA playoffs, expects Detroit's defense to be the difference once again in what should be a low-scoring Game 6 between the Eastern Conference foes.

Detroit is a 2-point home betting favorite, and our best Knicks vs. Pistons player props also see this as a matchup that's potentially short on scoring.

💰 Knicks vs. Pistons expert picks for Game 6

🔎 Our NEW NBA player prop odds tool can help you find the best NBA odds across legal sportsbooks in your area!

✅ Against the spread pick: Pistons -2 (-105 via Caesars) ⭐⭐⭐
✅ Moneyline pick: Pistons (-130 via BetRivers) ⭐⭐⭐
✅ Over/Under pick: Under 213.5 (-110 via BetRivers) ⭐⭐⭐⭐

🏀 Game 6 prediction & best bet

🎯 Score prediction: Pistons 107, Knicks 104

This is not your older siblings' Pistons squad, and the Knicks are finding that out quickly after allowing Detroit to pull off its first playoff win since 2007-08 in Game 2, and then again in Game 5 on Tuesday. The key to both wins for Pistons first-year head coach J.B. Bickerstaff has been defense and methodical offense.

In those two wins, the Pistons held New York to an average of 98.5 points per game, while scoring an average of just 103 points themselves. And in their near upset in Game 4, they fell by just one point in a brawling 94-93 loss at Madison Square Garden. Clearly, Bickerstaff knows the key to forcing a Game 7, and potentially winning this series, is by playing slow on offense and gritty on defense.  

The most important piece to that approach thus far has been big man Jalen Duren, who was 22nd in the league in defensive win shares this season (3.4), setting the tone for Detroit on the defensive end. He's averaging 2.0 blocks per game in the series and has the best defensive rating on the team (107.0) among players playing at least 20 minutes per game.

He's a big reason why the Over/Under is just 213.5 across our best sports betting apps, despite the Knicks being fifth in offensive rating during the regular season (118.5). Neither team has played as well offensively in the series as they did during the regular season, with New York seeing its effective field goal percentage drop from 55.6% to 50.8% against Detroit.

The Pistons have seen a similar drop-off going from a 54.7% effective field goal percentage in the regular season to 50.8% against Tom Thibodeau's squad. Cade Cunningham has really struggled with his shooting, too - 43% from the floor and 25% from behind the arc - and it's clear that if Detroit is going to win again, this game needs to be a low-scoring rock fight.

The Under cashed in three of the last four games in this series, and if it does again, a $10 bet pays a $9.09 profit.

✅ Best bet: Under 213.5 (-110 via BetRivers)

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🤖 AI prediction: Who will win Knicks vs. Pistons?

For entertainment purposes, we asked ChatGPT to analyze the Knicks and Pistons' season trends and how their first-round series has played out. Our AI prediction projects that the final score will be Pistons 104, Knicks 99.

🖥️ AI score prediction: Pistons 104, Knicks 99

🏀 Against the spread pick: Pistons -2 (-105 via Caesars)
🏀 Moneyline pick: Pistons (-130 via BetRivers)
🏀 Over/Under pick: Under 213.5 points (-110 via BetRivers)
🏀 Player prop pick: Tim Hardaway Jr. Over 2.5 made 3-pointers
🏀 Projected leading scorer: Jalen Brunson (31 points)
 

🤔 Betting takeaway: ChatGPT's AI prediction would mean the Pistons covering the spread as 2-point betting favorites (-105. ChatGPT is a large language model and not specifically designed for predicting sporting events, so these projections should be viewed as entertainment or a supplementary data point for your Knicks vs. Pistons betting research.

📈 Knicks vs. Pistons odds

Live updated odds from our best sports betting sites.

🪧 Game 6 opening odds

Opening odds via BetMGM.

  • Spread: Knicks +2.5 (-110) | Pistons -2.5 (-105)
  • Moneyline: Knicks +110 | Pistons -135
  • Over/Under: Over 212.5 (-115) | Under 212.5 (-105)

🚑 Knicks vs. Pistons injury report

Follow the official NBA injury report for more injury news.

📡 How to watch Knicks vs. Pistons live (Game 6)

📅 Thursday, May 1
🕗 7:30 p.m. ET
📍 Little Caesars Arena (Detroit)
📺 TNT, truTV | 🛜 Max

💵 Best NBA betting sites

Ready to bet on the NBA playoffs? Check out the best NBA betting sites and best sportsbook promos for today's games:

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Written By:
Rob Paul
Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.